Relationship Between Right Ventricular Glucose Metabolism and Right Heart Function in Patients With Dilated Cardiomyopathy
10.3969/j.issn.1000-3614.2015.08.011
- VernacularTitle:扩张型心肌病右心室心肌葡萄糖代谢与右心功能的相关性研究
- Author:
Daoyu WANG
;
Lei WANG
;
Yong YANG
;
Xinghong MA
;
Chaowu YAN
;
Shihua ZHAO
;
Wei FANG
- Publication Type:Journal Article
- Keywords:
Dilated cardiomyopathy;
Right heart function;
Glucose metabolism;
Positron emission tomography
- From:
Chinese Circulation Journal
2015;(8):762-765
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the relationship between right ventricular (RV) glucose metabolism by18F-fludeoxyglucose positron emission tomography (18F-FDG PET) and right heart function in patients with dilated cardiomyopathy (DCM).
Methods: The18F-FDG PET imaging was performed in 34 consecutive DCM patients, with the reference of Herrero method, the corrected RV standard uptake value (cRVSUV), corrected left ventricular standard uptake value (cLVSUV) and the ratio of RV to LV SUV (cR/L) were obtained. And all 34 patients received cardiac magnetic resonance imaging (cMRI) examination within 7 days, the left ventricular ejection fraction (LVEF) and RVEF were automatically calculated with Simpson’s principle. The pulmonary arterial systolic pressure was measured by echocardiography.
Results: The corrected cRVSUV and cR/L by18F-FDG PET were negatively related to RVEF by cMRI, (r=-0.513, P<0.01) and (r=-0.463,P<0.01) respectively, and meanwhile, the corrected cRVSUV and cR/L were also negatively related to LVEF, (r=-0.387,P<0.01 andr=-0.362,P<0.01) respectively.
Conclusion: Increased RV glucose metabolism closely related to RV dysfunction, the18F-FDG uptake value by PET might be used as an index for assessing the right heart function and prognosis in DCM patients.
