Toxicological assessment of antithrombotic small peptide RWR
- VernacularTitle:抗栓小肽RWR的毒理学试验研究
- Author:
Haifeng ZHENG
;
Haixia ZHAO
;
Shaohua WANG
;
Tao YANG
;
Lijun YANG
- Publication Type:Journal Article
- Keywords:
RWR;
toxicology;
safety
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the toxicological safety of antithrombotic small peptide RWR with independent intellectual property right. Methods Toxicity test in mice, mice bone marrow micronucleus assay, mice sperm abnormality test, and 30-day feeding test in rats were carried out in this study.ResuIts The MTD of acute toxicity test for rats was larger than 120 mg/kg.The results of bone marrow micronucleus assay, mice sperm abnormality test were all negative.Thirty-day feeding test had no adverse effects on body weight, food utility rate, organ coefficient, blood routine index of rats.There was also no histological changes related to RWR in lung, liver, spleen, kidney and heart of rats.ConcIusion RWR had no obvious toxicity on animal growth, hematopoietic function, kidney function and organ tissue and so on.
