Change of soluble P-selectin and soluble E-selectin levels in patients with type 2 diabetes mellitus with or without coronary heart disease
10.3969/j.issn.1000-484X.2015.09.022
- VernacularTitle:糖尿病及糖尿病并发冠心病患者血清sP-selectin、sE-selectin水平变化及意义
- Author:
Yanqiu LIU
;
Meihua GAO
;
Honglin LI
;
Changyin XIE
;
Haifei ZHANG
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes;
Prediabetes;
Type 2 diabetes mellitus with coronary heart disease;
Soluble P-selectin;
Soluble E-selectin
- From:
Chinese Journal of Immunology
2015;(9):1245-1249
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the vailation of serum sP-selectin,sE-selectin,levels in the patients of pre-diabetic,simple type 2 diabetes mellitus (T2DM) and T2DM with coronary heartdisease(CAD).To investigate the possible mechanism that sP-selectin, sE-selectin accelerate type 2 diabetes mellitus.Methods: Level of serum sP-selectin, sE-selectin was assayed by ELISA in type 2 diabetes with or without coronary heart disease (32 and 34 cases respectively),pre-diabetic (32 cases) and control group(32 cases). Meanwhile BMI,BP,FBS,FINS,TG,CHO,HDL-C,LDL-C,HbA1C were determined in all cases as well as in control group.Results:The serum levels of sP-selectin and sE-selectin in pre-diabetic,type 2 diabetes mellitus with or without coronary heart disease groups were significantly higher than the control group ( P<0.01 ).There was significant positive correlation between serum levels of sP-selectin,sE-selectin and these items including FBG ,FINS,TG,HbA1C,HOMA-IR(P<0.01);but sE-selectin was negatively correlated with HDL-C (P<0.05).Conclusion:sP-selectin,sE-selectin,are risk factors in the initiation and progression of pre-diabetic,type 2 diabetes with or without coronary heart disease;sP-selectin and sE-selectin possibly accelerate type 2 diabetes by inducing insulin resist-ance.
