Effect of conbercept ophthalmic injection on peripheral blood vascular endothelial growth factor, intraocular pressure and visual acuity in patients with age related macular degeneration
- VernacularTitle:康柏西普对年龄相关性黄斑变性患者外周血血管内皮生长因子、眼压及视力变化影响研究
- Author:
Rong LIU
;
Changming LIU
;
Na LI
;
Zheng ZHOU
;
Xiaodan WEI
;
Lele CUI
- Publication Type:Journal Article
- Keywords:
conbercept ophthalmic injection;
age-related macular degeneration;
vascular endothelial growth factor;
intraocular pressure;
visual acuity
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):104-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the effect of conbercept ophthalmic injection on peripheral blood vascular endothelial growth factor,intraocular pressure and visual acuity in patients with age related macular degeneration.Methods 60 patients who were diagnosed with age related macular degeneration were collected.All patients were randomly divided into experimental group and control group,30 cases in each group, lucentis intravitreal injection was given into the vitreous cavity in control group, experimental group give conbercept injection into the vitreous cavity,once a month.All patients were treated for 3 months,after the end of treatment,all patients serum VEGF and CRP,CMT,CNV and fluorescence leakage rate,intraocular pressure and visual acuity were detected.ResuIts After treatment,compared with control group,the content of serum VEGF was significantly lower in the experimental group(P<0.05).The content of serum CRP was significantly lower in experimental group(P<0.05).The CMT,CNV and fluorescence leakage rate were significantly lower in the experimental group (P<0.05).The level of IOP and visual acuity(logMAR)were significantly lower in the experimental group (P<0.05).ConcIusions Conbercept ophthalmic injection can reduce age-related macular degeneration patients week blood VEGF and CRP levels and decrease the CMT, CNV and fluorescence leakage rate, reduce intraocular pressure, visual acuity improvement and have guiding significance for clinic.
