Effect of resveratrol on levels of serum interleukin family of acute hemorrhagic shock patients and its protective effect for secondary heart and lung injury
- VernacularTitle:白藜芦醇对急性失血性休克患者部分血清白介素的影响及继发性心、肺损伤的保护作用研究
- Author:
Dongcai YUAN
;
Yincai LIU
;
Chunhua YI
- Publication Type:Journal Article
- Keywords:
resveratrol;
acute hemorrhagic shock;
interleukin family;
heart injury,lung injury
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):113-115
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of resveratrol on levels of serum interleukin family of acute hemorrhagic shock patients and study its protective effect for secondary heart and lungs injury.Methods 42 cases of acute hemorrhagic shock were collected and divided into experimental group and control group according to different drugs treatment, each group had 21 cases.Control group were given continuous low flow oxygen, fluid infusion and other basic treatment, given blood transfusion if necessary.On the basis of control group, experimental group was given resveratrol 30 mg/kg, orally, one time per day for 4 consecutive weeks.The life index were detected during the treatment period.Then the levels of serum CK, LDH, IL-6, IL-10, IL-12, LVP, +dp/dtmax ,-dp /dtmax and arterial blood gas of all patients were detected after treatment.ResuIts Compared with control group, the levels of CK and LDH in experimental group decreased significantly (P<0.05);IL-6, IL-10, IL-12 levels decreased significantly (P<0.05).LVP,+dp /dtmax , -dp /dtmax level increased significantly ( P<0.05 ); PaCO2 and pH levels decreased significantly, the level of PaO2 increased significantly (P<0.05).ConcIusion Resveratrol can significantly reduce the serum IL-6, IL-10, IL-12l, reduce the CK, LDH level of hemorrhagic shock patients, and alleviate the injury of heart and lung.
