Epithelial-mesenchymal transition and the airway remodeling of chronic obstructive pulmonary disease
10.16571/j.cnki.1008-8199.2015.09.023
- VernacularTitle:上皮间充质转化与慢性阻塞性肺疾病的气道重塑
- Author:
Hailan WU
;
Xiaofeng XIN
- Publication Type:Journal Article
- Keywords:
Epithelial-mesenchymal transition;
Chronic obstructive pulmonary disease;
Airway remodeling
- From:
Journal of Medical Postgraduates
2015;(9):1004-1008
- CountryChina
- Language:Chinese
-
Abstract:
Chronic obstructive pulmonary disease ( COPD) is a group of chronic airway inflammatory disease characterized by sustained airflow limitation and pulmonary function damage.Inflammation and tissue repair repeatedly result in airway remodeling.Now the mechanisms of airway remodeling remain unclear.More and more researches indicated that epithelial mesenchymal transition ( EMT) is crucial in the airway remodeling of COPD.EMT could be induced by various cell factors and signal channels in the airway epithelium, thus the airway remodeling happened.This review systematically introduces EMT and focuses on the relationship of EMT and airway remodeling of COPD and the probable mechanisms.
