Clinical observation of alprostadil, benazepril combined with Danqi Decoction and herbal enema in treatment of diabetic renal proteinuria
- VernacularTitle:前列地尔加贝那普利联合丹芪汤加中药灌肠治疗糖尿病肾病蛋白尿的临床观察
- Author:
Xingjian TANG
;
Pengzhi JIANG
- Publication Type:Journal Article
- Keywords:
diabetic nephropathy;
proteinuria;
Danqi Decoction;
herbal enema
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):149-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of alprostadil, benazepril combined with Danqi Decoction and herbal enema in treatment of diabetic renal proteinuria.Methods Sixty cases of diabetic renal proteinuria patients were randomly divided into the control group and the experimental group.Each group was 30 cases.The control group was given alprostadil(0.2μg/mL,2 times per day) and benazepril(10 mg,one time per day), while the experimental group was given Danqi Decoction combined with herbal enema on the basis of the control group(one time per day).The urea nitrogen, serum creatinine, quantitative of proteinuria (in 24 hours) and the excretion of urinary micro-albumin of both groups were all tested after three weeks of continuous treatment.ResuIts After three weeks of treatment, the laboratory values of urea nitrogen, serum creatinine, quantitative of proteinuria in 24 hours of both groups were all improved compared with those before treatment(P<0.05).Furthermore, the quantitative of proteinuria(in 24 hours) of the experimental group was significantly less than that of the control group(P<0.05), and the excretion of urinary micro-albumin of the experimental group was significantly less than that of the control group(P<0.05).ConcIusion The therapy of alprostadil, benazepril combined with Danqi Decoction and herbal enema is effective for diabetic renal proteinuria patients, and can significantly reduce proteinuria and renal injury.
