The clinical characteristics and risk factors of cerebral venous sinus thrombosis complicated by cerebral hemorrhage
10.3969/j.issn.1002-0152.2015.08.002
- VernacularTitle:颅内静脉系统血栓形成合并脑出血的临床特点与危险因素
- Author:
Zhang JIAN
;
Shi CHUNMEI
;
Zhou CHUNYAN
;
Xing SHIHUI
;
Li CHUO
;
Li JINGJING
;
Ou ZILIN
;
Hongchen BING
;
Tan SHUANGQUAN
;
Dang CHAO
;
Liu GANG
;
Zeng JINSHENG
- Publication Type:Journal Article
- Keywords:
Cerebral venous sinus thrombosis;
Cerebral hemorrhage;
Clinical characteristics;
Risk factor Out-come
- From:
Chinese Journal of Nervous and Mental Diseases
2015;(8):455-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the characteristics of clinical manifestations, risk factors, therapies and acute outcomes in patients with cerebral venous sinus thrombosis complicated by cerebral hemorrhage. Methods Seventy-five patients with cerebral venous sinus thrombosis were included in the study. According to the radiological findings on the brain image, patients were divided into two subgroups:cerebral hemorrhage group and non-hemorrhage group. The demo?graphic data, potential risk factors, clinical manifestations, radiological features, therapeutic strategies and acute out?comes were compared between two subgroups, and high risk factors were also analyzed. Results There were seventy-five patients with cerebral venous sinus thrombosis in the present study. Twenty-eight patients of them (37.2%) had cerebral hemorrhage whereas the remaining forty-seven patients (62.7%) did not have cerebral hemorrhage. Pregnancy/puerperi?um were significantly higher in patients with cerebral hemorrhage (with vs without;28.6%vs. 6.4%, P=0.015), while in?fection was markedly higher in patients without cerebral hemorrhage (with vs without;7.1% vs. 29.8%, P=0.021). Head?ache (92.9% vs. 70.2%, P=0.021), unconsciousness (25.0% vs. 6.4%,P=0.034), seizures (53.6% vs. 19.1%, P=0.002) and motor deficits (35.7% vs. 12.8%, P=0.019) were more common in patients with cerebral hemorrhage. Moreover, mul?tiple sinus involvement (1.4% vs. 44.7%, P=0.024) was significantly higher and the acute outcomes(mRS≥3: 46.4%vs.17.0%, P=0.006)were poorer in patients with cerebral hemorrhage. Binary Logistic analysis showed that pregnancy/pu?erperium (P=0.004) and multiple sinus involvement were positively, whereas infection was negatively correlated with cere?bral venous sinus thrombosis and hemorrhage ( P=0.007;P=0.03). Conclusions Pregnancy/puerperium, headache, uncon?sciousness, seizures, motor deficits and multiple sinus involvement are more frequently in patients with cerebral venous sinus thrombosis and hemorrhage, and the acute outcomes are poorer in patients with cerebral venous sinus thrombosis complicated by cerebral hemorrhage.
