Effects of low molecular weight heparin on patients with AECOPD:a meta-analysis
10.7644/j.issn.1674-9960.2015.08.012
- VernacularTitle:低分子肝素对慢性阻塞性肺疾病急性加重治疗效果的Meta分析
- Author:
Ling ZHOU
;
Jianing XI
- Publication Type:Journal Article
- Keywords:
chronic obstructive pulmonary disease;
acute exacerbation;
low molecular weight heparin;
meta-analysis;
system assessment;
randomized control trial
- From:
Military Medical Sciences
2015;(8):621-625
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estimate the effect of low molecular weight heparin (LMWH) combined with conventional treatment on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Literature on randomized control trials( RCTs) with AECOPD treated by LMWH combined with conventional methods was collected in PubMed.The studies were selected according to inclusive and exclusive criteria.The data were extracted,the quality was assessed, and meta-analysis was conducted with RevMan 5.2 software.Results There were twelve RCTs including 879 patients with AECOPD in the current study.The results of meta-analysis showed that:①LMWH could obviously improve PaO2 and PaCO2 of patients with AECOPD as compared with the control group.②There was no statistically significant difference between the LMWH-treated group and control group in the improvement of FEV1 or hematocrit.Conclusion LMWH can significantly improve arterial blood gas analysis in AECOPD, but does not improve FEV1 or hematocrit.
