Advances in research on relationships between complement 5a and acute lung injury

VernacularTitle:补体5a与急性肺损伤关系研究进展
Author: Limei YANG ; Jian ZHAO ; Rigao DING
Publication Type:Journal Article
Keywords: complement; C5a; acute lung injury; C5aR; C5L2
From: Military Medical Sciences 2015;(8):633-636
CountryChina
Language:Chinese
Abstract: Acute lung injury ( ALI) is a type of pulmonary excessive inflammation with high morbidity and mortality.It can be induced by multiple causes.There are currently no successful therapeutic or preventive measures because the patho-genesis of ALI has not been completely clarified.Many studies have shown that the activation of complement 5a (C5a) and its receptors is necessary in the process of ALI.Drug development targeting on C5a and its receptors may bring new hope to the treatment of ALI.In this article, the experimental evidence and possible mechanisms are summarized to reveal the rela-tionship between C5a and ALI.