Role of IL-12 family in autoimmune diseases
10.7644/j.issn.1674-9960.2015.08.016
- VernacularTitle:IL－12家族在自身免疫性疾病中的免疫调节作用
- Author:
Xiaoqian WANG
;
Chen XING
;
Yan LI
;
Beifen SHEN
;
Renxi WANG
- Publication Type:Journal Article
- Keywords:
IL-12;
IL-23;
IL-27;
IL-35;
autoimmune diseases
- From:
Military Medical Sciences
2015;(8):637-640
- CountryChina
- Language:Chinese
-
Abstract:
The interleukin-12 (IL-12) family, including IL-12, IL-23, IL-27,and IL-35, is characterized by unique structures and molecular partners.This is the only family of heterodimeric cytokines, which endows them with a unique set of connections and functional interactions.They not only play an important role in the regulation of inflammation, but are closely related to various autoimmune diseases.Here we discuss the structural aspects of these cytokines and their effect on some autoimmune diseases.
