Effect of Ginkgo biloba extract on serum DMT1, grp75 and neurological function in patients with Parkinson disease
- VernacularTitle:银杏叶提取物对帕金森患者血清黑质DMT1、葡萄糖调节蛋白75及神经功能的影响研究
- Author:
Fei WEI
;
Jie SHUAI
;
Lin SHEN
;
Zili GONG
;
Saiyu CHENG
- Publication Type:Journal Article
- Keywords:
Ginkgo biloba extract;
Parkinson disease;
substantia nigra DMT1;
glucose regulated protein 75;
nerve function
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):72-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Ginkgo biloba extract on serum divalent metal transporter1 ( DMT1 ) , glucose regulated protein 75(grp75) and nerve function in patients with Parkinson disease.Methods 38 cases of patients loith parkinson disease according to different drugs were divided into experimental group and control group, 19 cases in each group.Control group was treated with levodopa and Benserazide tablet, experimental group on the basis of control group, was given Ginkgo biloba extract tablets, treatment for 4 weeks.After treatment, DMT1, grp75 and cognitive function of all patients in substantia nigra were detected.ResuIts Compared with before treatment, two groups of patients with lower DMT1 level (P<0.05), compared with control group, experimental group of patients with lower DMT1 levels (P<0.05).Compared with pre-treatment, two groups of patients grp75 level was higher (P<0.05), compared with control group, experimental group after treatment grp75 level was higher (P<0.05).Compared with before treatment, the two groups of patients with MoCA scores were higher (P<0.05), HAMD scores were lower (P<0.05).Compared with control group, experimental group after treatment MoCA scores were higher (P<0.05), HAMD scores were lower (P<0.05).ConcIusion Ginkgo biloba extract can significantly reduce the level of DMT1 in the substantia nigra of Parkinson patients, increase the level of grp75, and improve the cognitive function.
