Effect of dual-antiplatelet drugs on S100β, IL-1β, adiponectin and NIHSS score in patients with acute cerebral infarction
- VernacularTitle:双联抗血小板药物对急性脑梗死患者血清S100β蛋白、白细胞介素1β、脂联素及神经功能评分的影响
- Author:
Pengfei LU
;
Jing LIU
;
Liyong YIN
;
Yajie ZHANG
;
Yulin WANG
;
Zhijie CUI
- Publication Type:Journal Article
- Keywords:
dual antiplatelet drugs;
acute cerebral infarction;
S100βprotein;
IL-1β;
adiponectin;
NIHSS score
- From:
Chinese Journal of Biochemical Pharmaceutics
2015;(8):75-77
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the effect of dual-antiplatelet drugs on S100β,IL-1β, adiponectin(ADPN)and NIHSS score in patients with acute cerebral infarction.Methods 58 patients diagnosed with acute cerebral infarction in first hospital of Qinhuangdao.All patients were collected and randomly divided into experimental group and control group according to random number table , 29 cases in each group.Both group were given the treatrnent of improvng the cerebral vascular circulation, protect brain cells, control blood pressure, blood glucose, oxygen when necessary.On the basis of conventional treatment, control group was treated with aspirin 200 mg, one time per day,orally.And experimental group was treated with clopidogrel 75 mg/d on the basis of control group,one time per day,orally.After treatment, the serum levels of S100β, IL-1β, ADPN and NIHSS score were detected in all patients.ResuIts After treatment, compared with control group,the serum S100βprotein level was significantly lower in the experimental group (P<0.05); the serum IL-1βlevel in experimental group was significantly lower (P<0.05);ADPN level in experimental group was significantly higher (P<0.05); NIHSS score of patients in experimental group was significantly lower (P<0.05).ConcIusions Dual antiplatelet drugs can reduce serum S100βprotein,IL-1βin serum of patients with acute cerebral infarction, increase the level of serum adiponectin, decrease NIHSS score, can effectively improre neurological function in patients with acute cerebral infarction.
