Protective effect of cytoglobin under hypoxia:An update
10.16571/j.cnki.1008-8199.2015.09.018
- VernacularTitle:新型缺氧保护因子胞红蛋白的研究进展
- Author:
Wei LI
;
Wenjing FAN
;
Shunlin QU
- Publication Type:Journal Article
- Keywords:
Cytoglobin;
Physiological functions;
Hypoxia;
Expression mechanism
- From:
Journal of Medical Postgraduates
2015;(9):978-983
- CountryChina
- Language:Chinese
-
Abstract:
As the fourth member of the globin family, cytoglobin ( CYGB) is a hypoxia-induced gene, and its expression is upregulated under hypoxia.CYGB is widely distributed in the living body and has a variety of physiological functions, such as anti-oxi-dative stress, anti-fibrosis, and neuroprotection.It also plays a protective role in cardiovascular disease, cancer, and other hypoxia-re-lated diseases.This article presents an overview on the structure and distribution of CYGB, its physiological functions of anti-fibrosis, anti-cancer and muscle regeneration, and the regulation and the mechanism of its expression under hypoxia.
