The role of PPARγin Alzheimer′s disease and its impact factors

VernacularTitle:PPARγ在阿尔茨海默病中的作用及影响因素研究进展
Author: Nan SONG ; Chuan QIN
Publication Type:Journal Article
Keywords: PPARγ; PPARγagonist; Gene expression regulation; Neuroprotection; Cy3G
From: Journal of Medical Postgraduates 2015;(9):989-994
CountryChina
Language:Chinese
Abstract: Alzheimer′s disease ( AD) , is a neurodegenerative disorder of the brain that is characterized by loss of memory and cognitive decline.At present, AD etiology remains unclear and there are no effective prevention and treatment measures in clinical practice.Peroxisome proliferator-activated receptorγ( PPARγ) is a ligand-regulated nuclear hormone receptor.Recent studies showed PPARγ-pathway played an important role in the pathogenesis of AD and some PPARγagonists have been proven to be neuroprotective in vitro and in vivo models.This paper reviews the roles of PPARγand related mechanisms in AD, summarizes affecting factors about PPARγpathway.Particularly, the effect of cyanidin-3-O-glucoside ( Cy3G) , one of the anthocyanidin glycoside forms, is a compound of naturally occurring phenolic compounds, suggesting the neuroprotective effect of Cy3G might be used as a potential natural PPARγagonist in the nervous system.