Effects of Total Alkaloids of Rhynchophylline on Baroreflex and Hypertensive Target Organs in Spontaneous Hypertensive Rats
10.3870/j.issn.1004-0781.2015.09.008
- VernacularTitle:钩藤总碱对高血压动脉压力感受反射和对高血压靶器官的作用?
- Author:
Yeling LIU
;
Zhongshi WANG
;
Xu ZHANG
- Publication Type:Journal Article
- Keywords:
Total alkaloids from Rhynchophylline;
Hypertension;
Injury,target organs;
Baroreflex
- From:
Herald of Medicine
2015;(9):1155-1157
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of total alkaloids from Rhynchophylline on hypertensive target organs. Methods 40 spontaneous hypertensive rats (SHRs) were divided into 4 groups as follows: normal control group,positive control with Tianma Goutengyin granule at 750 mg?d-1 ,total alkaloids from Rhynchophylline at 2.5 mg?day-1 as low dosage,and at 15.0 mg?d-1 as high dosage.All the rats were fed up for 20 weeks,and baroreflex sensitivity (BRS,in ms?mmHg-1)was determined by revised Smyth’s method.Heart,brain and kidney of the rats were sectioned for histological analysis at the end of 20th week. Results In sixteenth weeks,BRS of positive control,Tianma Goutengyin granule group,total alkaloids at low dosage and high dosage were(0.27±0.05),(0.31±0.06),(0.35±0.08),(0.34±0.08) ms?mmHg-1,respectively.BRS in SHR was not decreased except in the positive control.The treatment groups were superior to the normal control group in structure of heart,but not in the brain and kidney of the rats. Conclusion Total alkaloids from Rhynchophyllinecould protect heart from hypertensive injury.
