Clinical choice of prenatal diagnostic techniques
10.3760/cma.j.issn.1009-9158.2015.08.001
- VernacularTitle:产前诊断实验技术的临床选择
- Author:
Shiming LYU
- Publication Type:Journal Article
- Keywords:
Prenatal diagnosis;
High-throughput nucleotide sequencing;
Clinical laboratory techniques
- From:
Chinese Journal of Laboratory Medicine
2015;(8):505-507
- CountryChina
- Language:Chinese
-
Abstract:
Prenatal diagnosis is vitally important to control birth defects.The mature application of detecting biochemical markers in maternal serum and cytogenetic karyotype analysis of amniotic fluid cells , villi cells and umbilical cord blood cells , as well as the development of fluorescence in situ hybridization , nucleic acid amplification , gene sequencing , chips and other molecular biological techniques , have significantly improved the standards of prenatal diagnosis.The application of high-throughput sequencing , a non-invasive detection technique , ushers the development of prenatal diagnostic techniques into a new stage.In the face of a growing number of and constantly updated test items , it is necessary to assess the advantages and limitations of various prenatal diagnostic techniques , so as to realize scientific selection and combination, and utilize the techniques to their fullest potential.
