Effect of intraperitoneal hyperthermic chemotherapy on postoperative delirium in patients undergoing cytoreductive surgery
10.3760/cma.j.issn.0254.1416.2015.05.003
- VernacularTitle:腹腔内热灌注化疗因素对肿瘤细胞减灭术患者术后谵妄的影响
- Author:
Chang CHEN
;
Fan ZHANG
;
Zongze ZHANG
;
Mian PENG
;
Kai CHEN
;
Yanlin WANG
- Publication Type:Journal Article
- Keywords:
Delirium;
Postoperative complications;
Cytoreductive surgery;
Chemotherapy,cancer,regional perfusion
- From:
Chinese Journal of Anesthesiology
2015;(5):533-535
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of intraperitoneal hyperthermic chemotherapy ( IPHC) on postoperative delirium in the patients undergoing cytoreductive surgery ( CS) . Methods One hundred twenty patients of both sexes, aged 18-64 yr, weighing 40-70 kg, of ASA physical status Ⅰ-Ⅲ, scheduled for elective CS under general anesthesia, were enrolled in the study. According to whether or not the patients underwent IPHC, they were divided into 3 groups ( n=40 each): CS group, IPHC 1 h group (group IPHC1) and IPHC 2 h group (group IPHC2). IPHC1 and IPHC2 groups were perfused with chemotherapeutics for 1 and 2 h, respectively, after CS. Postoperative delirium was evaluated using the Confusion Assessment Method for the Intensive Care Unit at 1-3 days after surgery. Results The incidence of postoperative delirium was 15%, 28% and 38% in CS, IPHC1 and IPHC2 groups, respectively. The incidence of postoperative delirium was significantly higher in IPHC1 and IPHC2 groups than in group CS, and in group IPHC2 than in group IPHC1. Conclusion IPHC may increase the development of postoperative delirium in the patients undergoing CS.
