Histopathological characteristics of colonoscopic biopsy specimens of AIDS patients
10.3760/cma.j.issn.1674-2397.2015.04.009
- VernacularTitle:艾滋病患者结肠镜活检组织的病理学特征
- Author:
Yanhua XIAO
;
Hongbin LUO
;
Guanying XIAO
;
Junqing YI
;
Houzhi CHEN
;
Dandan WU
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
Colonoscopy;
AIDS-related opportunistic infections;
Pathology
- From:
Chinese Journal of Clinical Infectious Diseases
2015;(4):327-331
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the histopathological characteristics of colonoscopic biopsy specimens from AIDS patients .Methods A total of 310 clinically confirmed AIDS patients with abdominal pain, diarrhea or tenesmus were enrolled from Guangzhou NO .8 People’s Hospital during 2010 and 2014. All patients underwent colonoscopic examination , and the biopsy specimens were collected .Conventional HE staining, special stainings including Gomori’s methenamine silver ( GMS), Periodic Acid-Schiff stain (PAS), acid-fast staining, and immunohistochemical staining of cytomegalovirus (CMV) were performed. Results The biopsy specimens showed mucosa chronic inflammation (93.9%), epithelial degeneration and necrosis;the local erosion and ulcer formation were observed in severe cases .Among 310 patients, the infective pathogens were identified in 139 ( 44.8%) cases, including 47 ( 15.2%) cases with CMV infections, 36(11.6%) cases with mycobacterium infections , 21(6.8%) cases with penicillium marneffei infections, 10(3.2%) cases with Cryptococcus infections, 3(1.0%) cases with candida infections, 2(0.6%) cases with cryptozoite infections and the rest 20(6.5%) cases were with uncertain pathogens . Conclusion Chronic inflammatory lesions are common in patients with AIDS , and colonoscopic mucosal biopsy can help to identify the pathogens of intestinal opportunistic infection .
