High level of L1CAM predicting poor prognosis in hepatocellular carcinoma patients
10.3969/j.issn.1671-8348.2015.22.011
- VernacularTitle:肝癌患者高表达神经细胞黏附分子 L1预后差
- Author:
Shaofen YANG
;
Xiufang CHI
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
neural cell adhesion molecule L1;
prognosis
- From:
Chongqing Medicine
2015;(22):3055-3057
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance and prognostic value of PKD3 expression in human hepatocellu-lar carcinoma (HCC)after hepatectomy.Methods We analyzed mRNA expression of L1CAM in 1 10 HCCs by quantitative real-time PCR (qRT-PCR)and western blot,and the relationship among the overall survival of HCCs.Results The relative protein and mRNA expression level of L1CAM was up-regulated in HCCs comparing with adjacent non tumor liver tissues (P <0.01).L1CAM expression in the well-differentiated group was higher than that in the poor-differentiated group (P < 0.01 ).The expression of L1CAM mRNA was significantly correlated with tumor differentiation and TNM stage (P <0.05).The prognosis of patients with high expression L1CAM was poor (P <0.01).Conclusion L1CAM expression is related to occurrence and development of HCCs and may predict the prognosis of HCCs after hepatectomy.
