Study on the immunosuppressive activities of myeloid derived suppressor cells in patients suffering from recurrent spontaneous abortion

VernacularTitle:髓源抑制性细胞在复发性自然流产中的作用研究
Author: Yuhua LIU ; Zhaojun CHEN ; Lahong ZHANG ; Feng PAN ; Xiaoyin ZHENG ; Yuan YUAN ; Yang LIU
Publication Type:Journal Article
Keywords: Myeloid derived suppressor cell; Maternal immune tolerance; Recurrent spontaneous abortion
From: Chinese Journal of Microbiology and Immunology 2015;(6):448-452
CountryChina
Language:Chinese
Abstract: normal pregnancy and RSA (P=0.0250).Compared with women with normal pregnancy, those with RSA showed significantly decreased levels of Arg-1 ( P=0.0474) and suppressed activities of MDSCs against CD8+T cell proliferation (P=0.0230).Conclusion The MDSCs might play an important role in the main-tenance of maternal immune tolerance.Decreased number and inhibited function of MDSCs in the peripheral blood of women with RSA might be responsible for the development of RSA.