Study on the immunosuppressive activities of myeloid derived suppressor cells in patients suffering from recurrent spontaneous abortion
10.3760/cma.j.issn.0254-5101.2015.06.010
- VernacularTitle:髓源抑制性细胞在复发性自然流产中的作用研究
- Author:
Yuhua LIU
;
Zhaojun CHEN
;
Lahong ZHANG
;
Feng PAN
;
Xiaoyin ZHENG
;
Yuan YUAN
;
Yang LIU
- Publication Type:Journal Article
- Keywords:
Myeloid derived suppressor cell;
Maternal immune tolerance;
Recurrent spontaneous abortion
- From:Chinese Journal of Microbiology and Immunology
2015;(6):448-452
- CountryChina
- Language:Chinese
-
Abstract:
normal pregnancy and RSA (P=0.0250).Compared with women with normal pregnancy, those with RSA showed significantly decreased levels of Arg-1 ( P=0.0474) and suppressed activities of MDSCs against CD8+T cell proliferation (P=0.0230).Conclusion The MDSCs might play an important role in the main-tenance of maternal immune tolerance.Decreased number and inhibited function of MDSCs in the peripheral blood of women with RSA might be responsible for the development of RSA.
