Association between serum uric acid level and diabetic peripheral neuropathy in middle-aged and elderly ;population

VernacularTitle:中老年2型糖尿病患者血尿酸水平与糖尿病周围神经病变的相关性研究
Author: Guofeng WANG ; Ning XU ; Tao YANG
Publication Type:Journal Article
Keywords: Diabetes mellitus,type 2; Serum uric acid (SUA ); Diabetic peripheral neuropathy (DPN); Risk factors
From: Chinese Journal of Diabetes 2015;(7):608-611
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between serum uric acid (SUA ) level and diabetic peripheral neuropathy (DPN ) in middle‐aged and elderly population. Methods A total of 207 middle‐aged and elderly patients with T2DM were enrolled in this study. All the subjects were divided into two groups:T2DM only group and DPN group. The DPN group was further divided into three subgroups (mild ,moderate and severe group) according to TCSS score. Pearson correlation analysis was used to evaluate each index ,and binary logistic regression was used for statistical analysis of risk factors for DPN.Results SBP ,UACR ,BUN ,Scr ,TC ,LDL‐C and SUA were significantly higher in DPN group than in T2DM group. SUA were significantly increased together with the increase of the severity of DPN [(279.66 ± 56.53)vs(308.93 ± 52.96)vs(330.24 ± 48.79) μmol/L](P<0.05). Conclusion SUA level is an risk factor for the development of DPN in the middle‐aged and elders with T2DM. SUA is positively correlated with the severity of DPN.