Relationship between plasma cytokine changes and cardiac function in patients with heart failure
10.3969/j.issn.1008-0074.2015.04.07
- VernacularTitle:心力衰竭患者血浆细胞因子变化与心功能的关系
- Author:
Yongguo MIAO
- Publication Type:Journal Article
- Keywords:
Heart failure;
Cytokines;
Ventricular function
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(4):373-376
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the relationship between plasma cytokine changes and cardiac function in patients with heart failure.Methods:A total of 58 patients with heart failure treated in our hospital from Aug 2011 to Aug 2013 were selected as heart failure group,another 58 healthy people undergoing physical examination in our hospital during the same period were regarded as healthy control group.Enzyme linked immunosorbent assay (ELISA)was used to measure levels of C reactive protein (CRP),interleukin- 6 (IL-6),tumor necrosis factor-α (TNF-α), Th1/Th2 cytokine interferon-γ(IFN-γ)and interleukin-4 (IL-4),and the results were compared between two groups.Results:Compared with healthy control group,there were significant rise in levels of CRP [(3.57±1.15) mg/L vs.(6.21 ± 1.89)mg/L,(6.89 ± 2.02)mg/L,(7.57 ± 2.11)mg/L],TNF-α [(4.31 ± 2.09)ng/L vs. (13.97±3.24)ng/L,(16.23±3.59)ng/L,(18.55±3.61)ng/L]and IL-6 [(8.25±1.2)ng/L vs.(19.27±4.26) ng/L,(25.78±4.89)ng/L,(34.44± 6.12)ng/L];and significant increase in peripheral blood levels of IFN-γ[(48.21±7.52)pg/ml vs.(68.63±8.24)pg/ml,(73.91±10.14)pg/ml,(82.44±11.58)pg/ml]and IFN-γ/IL-4 [(1.07±0.12)vs.(1.73±1.26),(2.09± 1.31),(2.38± 1.40)]in patients with NYHA class Ⅱ,Ⅲ and Ⅳfrom heart failure group (P <0.05 all);and significant reduction in peripheral level of IL-4 [(45.11±6.97)pgl/ml vs.(35.31±5.47)pgl/ml,(34.56±4.92)pgl/ml]in patients with NYHA class Ⅲ and Ⅳ,P <0.05 both.The IFN-γand IFN-γ/IL-4 levels in patients with NYHA class Ⅲ and Ⅳ were significant higher than those of NYHA class Ⅱ,and those of NYHA class Ⅳ group were significant higher than those of NYHA class Ⅲ group,P <0.05 all.Conclusion:Plasma cytokine levels are closely related to cardiac function in patients with heart failure.
