Analysis of prognostic factors associated with survival in men with prostate cancer accompanied by spinal metastases at first diagnosis
10.3969/j.issn.1000-8179.2015.17.515
- VernacularTitle:初诊伴有脊柱转移的前列腺癌生存相关因素分析
- Author:
Luling SHAN
;
Xiuxin HAN
;
Chao ZHANG
;
Zhiwu REN
;
Shoulei LIANG
;
Guowen WANG
- Publication Type:Journal Article
- Keywords:
prostate cancer;
spinal metastasis;
chemotherapy;
endocrine therapy;
prognosis
- From:
Chinese Journal of Clinical Oncology
2015;(17):862-865
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Prostate cancer frequently metastasizes to the spine. In this study, we investigate the prognostic factors as-sociated with survival in patients with prostate cancer accompanied by spinal metastases at their preliminary diagnosis. Methods:Clin-ical data of 49 patients who were diagnosed with spinal metastasis from prostate cancer between January 2005 and December 2010 were analyzed. Variables including alkaline phosphatase (ALP), previous skeletal-related event, Gleason score, prostate-specific anti-gen (PSA) nadir, and time to castration resistance were obtained. Moreover, the relationship between these variables and overall sur-vival (OS) was analyzed. Survival analysis was performed by using Kaplan-Meier curves. Furthermore, the differences among the OS rates were assessed by using the log rank test. The variables were statistically significant in the univariate analysis (P<0.05) and were included in the multivariate model. Results:The average follow-up time was 64.1 months among the 49 patients. By the end of the follow-up, 41 of these patients were dead;the mean survival was 27 months. The 1-, 3-, and 5-year survival rate was 81.6%, 40.8%, and 20.4%, respectively. Univariate analysis identified that 6 variables were statistically significant prognostic factors of OS:with or without chemotherapy, ALP, previous skeletal-related event, Gleason score, PSA nadir, and time to castration resistance. The multivari-ate analysis showed that the time to castration resistance of ≥19 months and the addition of chemotherapy after disease progression are independent prognostic factors for a high OS. Conclusion:With or without chemotherapy and the time to castration resistance are the independent prognostic factors associated with survival in patients with prostate cancer accompanied by spinal metastases at first diagnosis.
