Research progress on cancer treatment targeting the Hippo-YAP signaling pathway
10.3969/j.issn.1000-8179.2015.17.779
- VernacularTitle:Hippo-YAP信号通路为靶点的肿瘤治疗研究进展
- Author:
Juan SONG
;
Xiaoqun YE
- Publication Type:Journal Article
- Keywords:
Hippo pathway;
YAP;
tumor;
G protein coupled receptors;
verteporfin;
metformin
- From:
Chinese Journal of Clinical Oncology
2015;(17):876-880
- CountryChina
- Language:Chinese
-
Abstract:
Hippo pathway is a signaling network involved in the regulation of cell proliferation and apoptosis, whereas Yes-asso-ciated protein (YAP) is the major effector of the pathway. YAP is a candidate oncogene, and dysregulation of the Hippo-YAP pathway is closely related to the occurrence and progression of various tumors. Therefore, Hippo-YAP may provide a novel therapeutic target for cancer treatment. Some drugs or compounds that regulate the Hippo-YAP pathway activity, such as verteporfin, can inhibit the occur-rence or growth of tumors. This review mainly focuses on the progress of studies on the use of Hippo-YAP signaling pathway as a tar-get of cancer treatment strategies.
