Preparation of glycyrrhizic acid liposomes and evaluation its liver targeting property in mice
10.3969/j.issn.1005-4847.2015.04.013
- VernacularTitle:甘草酸脂质体的制备及小鼠体内肝靶向效率的评价
- Author:
Benquan HU
;
Jiangping LIAN
;
Yue XU
;
Yan WANG
;
Yun ZHANG
;
Bo ZHANG
- Publication Type:Journal Article
- Keywords:
Glycyrrhizic acid;
Liposome;
Liver targeting property;
Mice
- From:
Acta Laboratorium Animalis Scientia Sinica
2015;(4):401-405
- CountryChina
- Language:Chinese
-
Abstract:
Objective To prepare liposomes of glycyrrhizic acid, and evaluate its liver targeting property in mice. Methods The liposomes were prepared with conventional rotary-evaporated film-ultrasonication method.The liposomes were injected into the mouse tail vein, and the concentration of glycyrrhizic acid was detected by RP-HPLC.The glycyrrhiz-ic acid injection was taken as control.The targeted indicators, including the relative tissue exposure ( re ) , targeting effi-ciency (te), and index of peak concentration ratio (Ce), were used to evaluate the liver targeting property.Results The re was 1.4, Te of the liposomes was 0.092, and te of the injection was 0.059.The Ce of the liver was 1.59, and the Ce of the blood was 0.99.Conclusion Compared with glycyrrhizic acid injection, the glycyrrhizic acid liposomes show good liv-er-targeting property.
