Protective effects of left-handed pantoprazole sodium on the rat model of gastric ulcer generated by pyloric ligation

VernacularTitle:左旋泮托拉唑钠对幽门结扎大鼠胃溃疡模型的治疗作用
Author: Yujuan TAN ; Yukui MA ; Chao FANG
Publication Type:Journal Article
Keywords: Left-handed pantoprazole sodium; pyloric ligation; gastric ulcer; pepsin; rat
From: Chinese Journal of Comparative Medicine 2015;(8):54-57
CountryChina
Language:Chinese
Abstract: Objective The aim of this study was to investigate the effect of left-handed pantoprazole sodium on rat models of gastric ulcer generated by pyloric ligation .Methods The rat models induced by pylorus ligation were treated with a single intravenous injection of left-handed pantoprazole sodium .The gastric ulcer inhibition rate , volume of gastric juice, activity of pepsin, and level of serum gastrin were determined and gastric mucosa tissue was examined by pathology . Results The gastric ulcer index , volume of gastric juice , activity of pepsin and level of serum gastrin in the rats pretreated with left-handed pantoprazole sodium (0.9, 1.8, 3.6 mg/kg, i.v.) were significantly lower than those in the model group .The lesions of gastric mucosa were also improved in the pantoprazole-treated groups .Conclusions Left-handed pantoprazole sodium has remarkable protective effects on the gastric mucosa in rat models of gastric ulcer induced by pyloric ligation.