The detection and analysis of serum IL-8 and IgA/C3 in henoch-schonlein purpura

VernacularTitle:过敏性紫癜患者 IL-8及 IgA/C3水平检测分析
Author: Hongbing QUAN ; Lin LI ; Jiaona LUO ; Guanghua LI ; Guodong YU ; Xianna WU ; Chunlong YANG
Publication Type:Journal Article
Keywords: henoch-schonlein purpura; interleukin-8; cytokine
From: International Journal of Laboratory Medicine 2015;(16):2354-2355
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between serum interleukin-8 (IL-8 )and immunoglobulin/complement 3A (IgA/C3)and immune imbalance in Henoch-Schonlein Purpura(HSP)in children,and provide evidence and guidance for clinical therapy of HSP.Methods Serum IL-8 was measured by Enzyme-linked immunosorbent assay(ELISA),and IgA and C3 were de-tected by automatic biochemistry analyzer,and calculate the ratio of IgA/C3.Results Serum IL-8 levels were (389±5 1.68)ng/L, significantly higher than that in healthy children (P < 0.05 ).Serum IgA levels were(306.2 ± 32.21 )mg/L,significantly higher (P <0.05).Serum C3 levels were (1 14.5 ±20.7)mg/L,of no statistical difference.IgA/C3 were (3.041 ±0.508 5),significantly higher(P <0.05).There was a positive correlation between IL-8 and IgA/C3 (r =0.534,P <0.05 ).Conclusion The children of HSP has cytokine and immunoglobulin disturbance,and presents a hyperreactivity in both humoral immunity and cellular immunity. Positive correlation between IL-8 and IgA/C3 was observed.