Influence of insulin on myocardial microcirculation in patients with type 2 diabetes mellitus complicat-ed coronary heart disease
10.3969/j.issn.1008-0074.2015.04.05
- VernacularTitle:胰岛素对2型糖尿病合并冠心病患者心肌微循环的影响
- Author:
Jianwen LIANG
;
Donghui ZHANG
;
Fensheng WU
- Publication Type:Journal Article
- Keywords:
Vascular resistance;
Diabetes mellitus,type 2;
Coronary disease
- From:
Chinese Journal of cardiovascular Rehabilitation Medicine
2015;24(4):366-369
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study influence of insulin on myocardial microcirculation of patients with coronary heart disease (CHD)complicated type 2 diabetes mellitus (T2DM)after percutaneous coronary intervention (PCI).Meth-ods:A total of 65 patients,who was confirmed as CHD by coronary angiography and fractional flow reserve (FFR)<0.75 measured by pressure guidewire,were enrolled.After drug-eluting stent implantation,index of microcircula-tion resistance (IMR)was measured.According to insulin usage or not,they were divided into insulin therapy group (insulin group,n=30)and pure oral hypoglycemic agent therapy group (pure hypoglycemic agent group,n=35). After six-month follow up,IMR was reviewed,and IMR was compared between two groups.Results:There was no significant difference in incidence rate of major adverse cardiovascular events (MACEs)between two groups,P =0.07. On six months after PCI,IMR in insulin group was significantly lower than that of pure hypoglycemic agent group [(24.5±3.1)U vs.(30.2±4.3)U,P <0.05].Conclusion:Insulin therapy can improve myocardial micro-circulation in patients with coronary heart disease complicated type 2 diabetes mellitus after PCI.
