The clinical value of plasma M type phospholipase A2 receptor antibody and IgG subtypes deposition in diagnosis of hepatitis B virus-associated membranous nephropathy
10.3969/j.issn.1673-4130.2015.16.047
- VernacularTitle:M 型磷脂酶 A2受体抗体及免疫球蛋白 IgG 亚型在乙型肝炎病毒相关膜性肾病中的检测?
- Author:
Jun LI
;
Li ZHUO
;
Hongmei GAO
;
Jianhua LU
;
Guming ZOU
;
Wenge LI
- Publication Type:Journal Article
- Keywords:
M type phospholipase A2 receptor antibody;
IgG subtypes;
idiopathic membranous nephropathy;
hepatitis B virus-associated membranous nephropathy
- From:
International Journal of Laboratory Medicine
2015;(16):2401-2403
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the different expressions of plasma M type phospholipase A2 receptor antibody and IgG subtypes deposition of kidney tissues in idiopathic membranous nephropathy and hepatitis B virus-associated membranous nephropa-thy,and to evaluate the significance of plasma M type phospholipase A2 receptor antibody and IgG subtypes in diagnosis of hepatitis B virus-associated membranous nephropathy.Methods Plasma samples were obtained from patients with idiopathic membranous nephropathy,hepatitis B virus-associated membranous nephropathy and minimal change disease,respectively,before immunosup-pressive therapy.Concentration of plasma M type phospholipase A2 receptor antibody was detected by sandwich ELISA and concen-tration of IgG subtypes were measured by immunofluorescence.Results Concentration of plasma M type phospholipase A2 receptor antibody was (15.4±7.2)μg/mL in idiopathic membranous nephropathy group,higher than that in the hepatitis B virus-associated membranous nephropathy group (10.3±5.7)μg/mL (P <0.01),between idiopathic membranous nephropathy group and hepatitis B virus-associated membranous nephropathy group.There was no distinct difference of IgG subtypes deposition in glomerlar capil-lary wall.Conclusion There is obvious clinical significance of concentration of plasma M type phospholipase A2 receptor antibody in differential diagnosis of idiopathic membranous nephropathy and hepatitis B virus-associated membranous nephropathy,while no distinct significance of IgG subtypes deposition.
