Clinical effects of recombinant mutant human tumor necrosis factor on the malignant pleural effusion in-duced by lung adenocarcinoma
10.16571/j.cnki.1008-8199.2015.08.012
- VernacularTitle:重组改构人肿瘤坏死因子对肺腺癌致恶性胸腔积液封胸治疗的临床疗效分析
- Author:
Xinwu XIAO
;
Qian LI
;
Yong SONG
;
Wenkui SUN
- Publication Type:Journal Article
- Keywords:
Lung adenocarcinoma;
Malignant pleural effusion;
Recombinant mutant human tumor necrosis factor;
Treatment
- From:
Journal of Medical Postgraduates
2015;(8):836-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study aimed to observe the clinical effects and the adverse reactions of recombinant mutant human tumor necrosis factor-alpha ( rhu-TNF) on the treatment of malignant pleural effusion ( MPE) induced by lung adenocarcinoma . Methods 70 patients with MPE caused by lung adenocarcinoma hospitalized in our department were chosen as the research objects . After conventional drainage of pleural effusion , the patients were divided into two groups according to the weight , respectively receiving intra pleural injection of 2 000 000 units and 3 000 000 units of rhu-TNF, followed by the observation of clinical effects and adverse reac-tions.A further retrospective analysis were made on the effects of dexamethasone injected before operation on clinical effects and ad -verse events. Results The effective rates of 2 000 000 unit group and 3 000 000 unit group were respectively 75.68%and 87.88%(P=0.23), with no statistical difference.The adverse reactions in the group of patients being injected dexamethasone before operation significantly reduced(P=0.021) and the use of dexamethasone had no influence on the efficacy of rhu-TNF ( P=0 .486 ) . Conclusion Rhu-TNF is a safe drug with high efficiency in the treatment of MPE induced by lung adenocarcinoma , and the efficacy and safety of re-peated application in clinic still need more supporting data .
