The pathophysiological mechanisms of HIV-related neuropathic pain

VernacularTitle:人类免疫缺陷病毒相关神经病理性疼痛的病理生理学机制
Author: Qiang CHEN ; Shanshan QIN ; Changshui XU
Publication Type:Journal Article
Keywords: Human immunodeficiency virus; Glycoprotein 120; Neuropathic pain; Sensory neuropathy
From: Journal of Medical Postgraduates 2015;(8):860-864
CountryChina
Language:Chinese
Abstract: HIV-related sensory neuropathy ( HIV-SN) mainly contains the HIV infection-related distal sensory polyneuropa-thy (DSP) and antiretroviral toxic neuropathies (ATN).HIV-DSP is associated with proinflammatory cytokines , chemokines, ros and which is induced by gp 120;and HIV-ATN may be related to mitochondrial toxicity which is induced by the application of anti retroviral drugs, such as ddC, and similar as the molecular mechanism of HIV-DSP, this means that the current conventional method for the treatment of neuropathic pain in AIDS may further aggravate the neuropathic pain of the patient .Therefore, developing the study on the neurochemical and pharmacological mechanisms of HIV-related neuropathic pain will provide novel targets for the new effective drugs .