Effect of heparin slow-release stent on angiogenesis and cardiac function of patients with acute myocardial infarction
10.3969/j.issn.2095-4344.2015.30.012
- VernacularTitle:肝素缓释支架置入急性心肌梗死患者后的血管再生及心肌功能改善
- Author:
Jinru ZHANG
;
Dongmei WANG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;19(30):4815-4819
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Bare-metal stent for treatment of myocardial infarction may improve cardiac function to some extent, but it is prone to induce thrombus. OBJECTIVE:To explore the effect of heparin slow-release stent on angiogenesis and cardiac function of patients with acute myocardial infarction. METHODS:A total of 87 patients with acute myocardial infarction were enroled, including 47 males and 40 females, aged 55-81 years. These patients were divided into observation group (n=45) with percutaneous coronary intervention with heparin slow-release stent and control group (n=42) with percutaneous coronary intervention with bare metal stent. The folow-up period was 12 months, and angiogenesis, cardiac function improvement and adverse cardiac events in the two groups were observed and compared. RESULTS AND CONCLUSION:The new blood vessel density, myocardial survival area and left ventricular ejection fraction were al higher in the observation group than the control group (P < 0.05). At 3 months after intervention, there was one case of revascularization and one case of recurrent acute myocardial infarction in the observation group; in the control group, there was case of revascularization, one case of recurrent acute myocardial infarction and one case of sudden cardiac death, and there was no difference between the two groups. These findings indicate that that percutaneous coronary intervention with heparin slow-release stent has good biocompatibility and can effectively promote the regeneration of blood vessels and improve cardiac function of patients with acute myocardial infarction.
