Research on the Model of Combining Myocardial Ischemic Coronary Disease with Syndrome of Kidney Deficiency and Blood Stasis
10.3969/j.issn.1005-5304.2015.09.016
- VernacularTitle:心肌缺血型冠心病肾虚血瘀病证结合模型研究
- Author:
Shengfang ZHOU
;
Ruxiu LIU
;
Linlin YIN
;
Hewei LUO
;
Hui LI
;
Xuanke GUAN
- Publication Type:Journal Article
- Keywords:
myocardial ischemic coronary disease;
animal model;
kidney deficiency and blood stasis;
combination of disease and syndrome;
rats
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2015;(9):56-59
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the feasibility of establishing the model of combining myocardial ischemic coronary disease with syndrome of kidney deficiency and blood stasis by surgical method.Methods Non-disease of kidney deficiency and blood stasis syndrome model was built by taking the methods of fright, being placed in a cold environment and injection of hydrocortisone. The model of combining the myocardial ischemic coronary disease with the syndrome of kidney deficiency and blood stasis was established through ligating the left anterior descending branch of artery and injecting hydrocortisone. The rats were divided into kidney deficiency and blood stasis group, combination of disease and syndrome group, and normal group, 5 rats in each group. The temperature, weight, heart rate, breathing rate and whole blood viscosity, casson viscosity of the rats in the two groups before and after modeling were observed. According to TCM clinical diagnosis criteria of kidney deficiency and blood stasis syndrome, TCM syndrome characteristics of the two groups were compared.ResultsCompared with normal groups and before modeling, rat temperature dropped and breathing rate increased in kidney deficiency and blood stasis group, combination of disease and syndrome group (P<0.05). Compared with normal group, rat weight decreased or grew slowly, and whole blood viscosity and casson viscosity increased (P<0.05, P<0.01). There were statistical significant differences in whole blood viscosity and electrocardiogram between the two groups (P<0.05).Conclusion There is no obvious difference between TCM syndrome characteristics of the two groups. They all meet the TCM clinical diagnosis criteria of kidney deficiency and blood stasis syndrome.
