Pathological study on the lens of rats with spontaneous congenital cataract
10.16571/j.cnki.1008-8199.2015.08.008
- VernacularTitle:先天性白内障大鼠晶状体的病理学研究
- Author:
Xiaoyun TIAN
;
Bo WU
;
Rusong ZHANG
;
Jinwei YOU
;
Changlin ZHAO
;
Lei LIANG
;
Shifeng YUN
- Publication Type:Journal Article
- Keywords:
Congenital cataract;
Lens;
Pathology
- From:
Journal of Medical Postgraduates
2015;(8):820-823
- CountryChina
- Language:Chinese
-
Abstract:
Objective There are a few reports on rats with spontaneous congenital cataract in China .The purpose of this study was to investigate the morphological changes of lens in rats with spontaneous congenital cataract . Methods 24 d, 1-year rats with cataract and microphthalmos cataract and normal rats (n=5) were selected as research objects .Their lens were observed by a slit lamp microscope and taken photos in front of them , followed by examination through light micrograph and transmission electron micros-copy. Results Rats with microphthalmos cataract showed narrowed palpebral fissure and broaden nucleus while rats with cataract showed normal palpebral fissure and narrowed nucleus .As for 24 d,1-year rats with microphthalmos cataract , the fibers of their lens showed derangement and vacuole-like degeneration by light microscope , in addition, the abnormal connection between fiber cells were observed by electron microscopy .As for 1-year normal rats , the fibers were in consistent structure and regular arrangement without cell ingredient . Conclusion The appearance and morphological changes of the lens in rats with spontaneous congenital cataracts are in consistence with the pathological changes of cataracts , which is appli-cable in further research on the pathogenesis of cataract .
