Correlation of the serum S100βprotein level with early postoperative cognitive dysfunction in infants after propofol or etomidate anesthesia
10.16571/j.cnki.1008-8199.2015.08.009
- VernacularTitle:血清 S100β蛋白水平与丙泊酚及依托咪酯麻醉后幼儿早期认知功能障碍的相关性研究
- Author:
Yihong JIANG
;
Jingyuan XIE
;
Weiwei XIONG
;
Zhihua HUANG
;
Aiguo LI
;
Yi TAN
;
Lingyun PENG
- Publication Type:Journal Article
- Keywords:
Propofol;
Etomidate;
Infant;
S100βprotein;
Postoperative cognitive dysfunction
- From:
Journal of Medical Postgraduates
2015;(8):824-828
- CountryChina
- Language:Chinese
-
Abstract:
Objective There is a lack objective methods for the diagnosis of postoperative cognitive dysfunction (POCD).This study aimed to investigate the influence of propofol or etomidate anes-thesia on the postoperative cognitive function and serum S 100βprotein level in infants . Methods This study included 100 hernia infants aged 1-3 years treated by laparoscopic herniorrhaphy under propofol (n=50) or etomidate anesthesia (n=50).At 1 day before and 3 days after surgery, we assessed the cognitive function of the patients using Bayley Scales of Infant and Toddler Development ( BSID-Ⅲ) and further divided each group into a POCD and a non-POCD sub-group based on the results of diagnosis made according to the Z-scores.Using ELISA, we measured the levels of the serum S100βpro-tein in the iliac venous blood drawn preoperatively ( T0 ) and before PACU ( T1 ) and compared them between the POCD and non-POCD groups. Results At 3 days after operation, POCD was observed in 10 cases (20.0%) in the propofol group and 9 cases (18.0%) in the etomidate group, with no statistically significant differences between the two (P>0.05).The level of the serum S100βprotein was markedly elevated in both the propofol and etomidate groups at T 1 as compared with that at T0(P<0.05), and so was it in the POCD in comparison with that in the non-POCD group (P<0.05), with no statistically significant differences between the two groups at T1(P>0.05).A significant correlation was found between the postoperative S 100βlevel and POCD at 3 days after surgery in both the propofol (r=0.842, P=0.001) and the etomidate group (r=0.821, P=0.001). Conclusion Propofol and etomidate anes-thesia can induce different degrees of postoperative decline of cognitive function in 1-3 years old infants .The post-anesthesia elevation of the serum S100βprotein level is positively correlated with early postoperative POCD and indicates various degrees of brain damage .
