Clinical efficacy of levocarnitine in the treatment of non-alcoholic fatty liver

VernacularTitle:左卡尼汀对非酒精性脂肪肝的疗效观察
Author: Yunpeng YOU ; Dadong ZHENG ; Ying WANG ; Yong ZHONG ; Shiyong PAN
Publication Type:Journal Article
Keywords: Levocarnitine; Non-alcoholic fatty liver; Clinical efficacy
From: Journal of Medical Postgraduates 2015;(8):847-849
CountryChina
Language:Chinese
Abstract: Objective Non-alcoholic fatty liver ( NAFL) is a metabolic disease and levocarnitine can be used to improve the energy metabolism of the patient .This study aimed to evaluate the clinical efficacy of levocarnitine in the treatment of NAFL . Methods We retrospectively analyzed 85 cases of NAFL treated by lifestyle intervention (control group, n=40) or by lifestyle intervention +levo-carnitine medication (medication group, n=45).In addition to lifestyle intervention, the patients in the medication group received oral levocarnitine at 10 mL tid for 4 weeks followed by a reduced dose of 10 mL bid for another 8 weeks. Results Twelve weeks after treat-ment, 37 cases (82.2%) in the medication group showed remarkable improvement and the other 8 failed to respond.In the control group, 23 cases (57.5%) were improved and 17 cases remained unimproved .There were statistically significant differences in the rate of therapeutic effectiveness between the two groups of patients (P<0.01).No adverse effects were observed during the levocarnitine medi-cation. Conclusion Lifestyle intervention +levocarnitine medication can improve NAFL .