Emerging role of high mobility group protein B1 in pulmonary fibrosis
10.16571/j.cnki.1008-8199.2015.08.022
- VernacularTitle:高迁移率族蛋白 B1在肺纤维化中作用的研究进展
- Author:
Qiong WANG
;
Guoqian CHEN
;
Jingyu CHEN
- Publication Type:Journal Article
- Keywords:
High mobility group protein B 1;
Pulmonary fibrosis;
Molecular targeted therapy
- From:
Journal of Medical Postgraduates
2015;(8):875-879
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary fibrosis , an important cause of pulmonary diseases , has no effective protective and therapeutic meas-ures.Recent studies showed high mobility group protein B 1 (HMGB1) has an important role in the development of pulmonary fibrosis and many HMGB1 antagonists can alleviate pulmonary fibrosis in animal models .This paper summarizes the structure , function, intra-cellular signal transduction of HMGB1, the expression change of HMGB1 in pulmonary fibrosis and HMGB1 targeted therapy in pulmo-nary fibrosis in order to provide an effective basis for clinical treatment of pulmonary fibrosis .
