Evaluation of Several Inflammatory Markers to Infectious and Gouty Arthritis

VernacularTitle:炎症标志物在感染性和痛风性关节炎中鉴别诊断的应用价值
Author: Nan WAN ; Lu WANG ; Dongya MENG ; Wei ZHENG ; Xiaofang HU
Publication Type:Journal Article
Keywords: inflammatory markers; septic arthritis; gouty arthritis
From: Journal of Modern Laboratory Medicine 2015;(3):142-144
CountryChina
Language:Chinese
Abstract: Objective The aim of this study was to investigate which inflammatory markers allow an accurate differentiation of septic and gouty arthritis.Methods In 2013 January to 2014 January 33 patients with septic arthritis and 29 patients with gouty arthritis.Detected white blood cells,C-reactive protein and uric acid of inflammatory markers in plasma and tested lac-tate,glucose,uric acid,lactate dehydrogenase and white blood cell count inflammatory markers in the synovial fluid.MedCalc 13.0 software were used for statistical analysis.Results There were no significantly different between serum C-reaction protein and WBC counts with two groups.Synovial lactate showed the greatest diagnostic potential (AUC=0.898,sensitivi-ty=96.9%,specificity=72.4%)followed by serum uric acid (AUC=0.818)and synovial uric acid (AUC=0.808).Con-clusion Lactate in the synovial fluid has excellent diagnostic potential to differ septic arthritis from gouty arthritis.Synovial lactate levers above 1.7 mmol/L almost proofed septic arthritis.