Clinical Application of Myeloperoxidase in Diagnosis and Prognosis of Non-ST Elevation Acute Cornary Syndromes
10.3969/j.issn.1671-7414.2015.03.022
- VernacularTitle:髓过氧化物酶在非 ST 段抬高急性冠状动脉综合征诊断和预后中的临床应用
- Author:
Hongbo YU
;
Yang LIU
;
Junqing LUO
;
Xinguo LIU
;
Ming JIAN
;
Meiliang HUANG
;
Dan LUO
;
Xuefeng LI
- Publication Type:Journal Article
- Keywords:
non-ST-elevation acute coronary syndrome(NSTE ACS);
myeloperoxidase
- From:
Journal of Modern Laboratory Medicine
2015;(3):77-79
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of myeloperoxidase (MPO)in diagnosis of non-ST elevation acute cor-onary syndromes (NSTE ACS).Methods The MPO was determined in 61 unstable angina pectoris (UAP)patients and 54 non-ST-elevation myocardial infarction (NSTE MI)patients,then analyzed the data with receiver operationg characteristic curve (ROC curve)statistical software.The major adverse cardiac events (MACE)were obseved in 106 NSTE ACS patients through 1 year of follow-up.Results The MPO values of NSTE MI group and UAP group were 672±418 ng/ml and 459± 328 ng/ml,the difference was statistically significant (t=3.928,P <0.001).The cTnI values were 558±261 pg/ml and 405 ±278 pg/ml of respectively.The difference was statistically significant (t = 3.089,P = 0.003).The area under the ROC curve of MPO was 0.726 when the optimal cutoff value was 382 ng/ml in the diagnosis of NSTE MI.The sensitivity and specificity was 92.6% and 39.8%.The area under the ROC curve of cTnI was 0.799 when the optimal cutoff value was 484 ng/ml in the diagnosis of NSTE MI.The sensitivity and specificity was 65.5% and 92.3%.High MPO maintained a strong association with the risk of major adverse cardiac events through 1 year of follow-up.Conclussion MPO is ahigh sensitivity marker of the NSTE MI and of clinical value for prognosis of NSTE ACS.
