Role of Detecting GADA and ZnT8A in Newly Diagnosed Type 2 Diabetes Patients
10.3969/j.issn.1671-7414.2015.03.014
- VernacularTitle:新诊断2型糖尿病患者GADA 和 ZnT8A 自身抗体检测意义研究
- Author:
Changsheng ZHAO
;
Qian DONG
;
Haitao ZHANG
;
Xiqin YANG
;
Zhao ZHAO
;
Guohua WANG
;
Yanfeng ZHAO
;
Heqiu ZHANG
;
Xiaoyan FENG
- Publication Type:Journal Article
- Keywords:
newly diagnosed type 2 diabetes;
latent autoimmune diabetes in adults;
glutamic acid decarboxylase autoantibody;
zinc transporter 8 autoantibody
- From:
Journal of Modern Laboratory Medicine
2015;(3):50-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the positive rates of glutamic acid decarboxylase autoantibody (GADA)and zinc transporter 8 autoantibody (ZnT8A)in newly diagnosed type 2 diabetes patients.Methods GADA and ZnT8A were detected in 101 ca-ses of newly diagnosed type 2 diabetes mellitus patients using ELISA.Results The positive rate of GADA was 21.78%,the positive rate of ZnT8A was 17.82%,and the common positive rate of GADA and ZnT8A was 8.91%.There were no corre-lations between GADA or ZnT8A autoantibodies and the patient’s sex (t=-0.724,-0.550;0.903,1.359,P >0.05),age (t=-0.724,-0.550;0.903,1.359,P >0.05),blood glucose (r=0.290,0.110;-0.264,-0.047,P >0.05),cholesterol (r=-0.047,0.004;0.154,-0.138,P >0.05),triglyceride (r=-0.092,-0.054;-0.217,-0.023,P >0.05),and low density lipoprotein (r= - 0.045,- 0.027;0.202,- 0.025,P > 0.05).Conclusion It should be screened autoantibodies timely for newly diagnosed type 2 diabetic patients in order to diagnosis the Latent autoimmune diabetes in adults early.
