Diagnostic Value of Combined Measuring of Serum Cystatin C and 24 h Urine Microalbumin in Early Gestational Diabetes Kidney Disease
10.3969/j.issn.1671-7414.2015.02.044
- VernacularTitle:血清Cys C和24h尿微量清蛋白定量联合检测对妊娠期糖尿病肾病的早期诊断价值
- Author:
Dongna WU
;
Wenjie ZHANG
;
Zhaoping TANG
;
Yong ZHOU
;
Yafeng WANG
;
Junfeng HAN
;
Hui JIA
- Publication Type:Journal Article
- Keywords:
Cys C;
urine microalbumin;
joint detection;
diabetic nephrosis
- From:
Journal of Modern Laboratory Medicine
2015;(2):139-141
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnostic value of serum Cystatin C and 24 h urine microalbumin quantitative exami-nation in the early gestational diabetes kidney.Methods Chose 110 cases of patients from 37 to 40 weeks during pregnancy with gestational diabetes.According to the GFR,patients were divided into GFR moderate decline group A (30 ml/min/1.73m2 ≤GFR<60ml/min/1.73m2 ,n=30),GFR mild decline group B (60 ml/min/1.73m2 ≤GFR<89 ml/min/1.73m2 ,n=42)and GFR normal group C (GFR≥90 ml/min/1.73 m2 ,n=38).Choose the same gestational weeks 40 healthy preg-nants cases as control group D.Statistics of four groups of serum Cys C,24 h urine microalbumin quantitative,serum urea and creatinine,then analize.Results The levels of serum cystatin C and urine microalbumin compared between each group respectively,the differences were statistically significant (F=31.209,34.698,P <0.01,respectively).The levels of blood u-rea and creatinine in group A when compared with the other groups,found that the difference was statistically significant (F=5.845,4.575,P <0.01,respectively).When comparing the levels of blood urea and creatinine among the groups B,C and D,there was no statistical difference of significance (P >0.05).There was positive correlation between levels serum Cys C and urine microalbumin in group A and B (r=0.756,0.725,t=5.209,4.835,P <0.01,respectively).The sensitivity of Cys C and urine microalbumin were 95.2% and 90.5%,sensitivity of the combination of Cys C and urine microalbumin was 100% (χ2 =8.24,7.08,P <0.05,respectively).Conclusion As sensitive indicators of gestational diabetes in the early renal damage stage,joint detection of Cys C and urine microalbumin is of great significance for diagnosis and monitoring of diabe-tes in the early renal damage stage.
