Recognition of Ubiquitination Signal with Ubiquitin-binding Domains
10.3969/j.issn.1671-7414.2015.02.031
- VernacularTitle:泛素结合结构域与泛素化信号的识别
- Author:
Jingwei WANG
- Publication Type:Journal Article
- Keywords:
ubiquitin;
ubiquitin binding domain;
recognition;
regulatory mechanism
- From:
Journal of Modern Laboratory Medicine
2015;(2):99-104
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitylation is a highly versatile post-translation modification that controls virtually all types of cellular events by changing the molecular landscape,the three-dimensional structure,the location or activity of the substrate,influencing the interactions of substrate with other proteins.Many cellular activities of ubiquitin and its functions are deciphered by specific ubiquitin binding domains (UBDs).UBD interacts with the different type of Ubiquitylation with a variety of lengths and linkage patterns based on the specific functional surfaces.So far over twenty distinct UBD families have been identified,and the known members of this group have expanded rapidly.The UBD families,the decoder of ubiquitylation network,are build-ing a foundation for in-depth understanding the ubiquitination proteomics “ubiquitome”.
