Detection and Significance of Anti-β2 Glycoprotein 1 Antibodies in Female Infertility and Threatened Abortion
10.3969/j.issn.1671-7414.2015.02.013
- VernacularTitle:抗-β2糖蛋白1抗体在女性不孕症及先兆性流产中的检测及意义
- Author:
Na LI
;
Yang RONG
;
Zhenguang WANG
- Publication Type:Journal Article
- Keywords:
anti-β2 glycoprotein 1 antibodies;
infertility;
threatened abortion;
irregular menses
- From:
Journal of Modern Laboratory Medicine
2015;(2):42-45
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis the correlation of the anti-β2 glycoprotein 1 antibodies in female infertility and threatened a-bortion.Methods Selected 547 patients with female infertility,229 patietns with threatened abortion,229 patietns with ir-regular menses and 31 normal female between August 2013 to January 2014.All the anti-β2 glycoprotein 1 antibodies (Ig-G/Ig-M)were detected by ELISA.Detected the anti-β2 glycoprotein 1 antibodies (Ig-G/Ig-M)of 114 patients who treated with aspirin and prednisone combined with gamma globulin.Results The positive rate of anti-β2GP1 antibodies (Ig-G/Ig-M)of female infertility,threatened abortion,irregular menses and normal female were 0.36%,0.43%,1.6%,0% and 20.29%, 19.21%,8.3% and 3.2%,respectively.The positive rate of aβ2GP1-IgM of female infertility,threatened abortion,irregular menses were higher than normal female.The anti-β2GP1-IgM of the treated female infertility were 47.14± 34.85 RU/ml and 31.14±27.64 RU/ml,respectively.The anti-β2GP1-IgM of the treated threatened abortion were 37.75±31.20 RU/ml and 24.34±24.48 RU/ml,respectively.The levels of anti-β2GP1-IgM of the treated patietns were significantly lower than before.Conclusion There was a close relationship between anti-β2GP1-IgM antibodies and female infertility and threatened abortion,anti-β2GP1-IgM antibodies maybe one of the immune factors for female infertility and threatened abortion.
