Clinical Value of Serum Sialic Acid Detection for Diagnosis in Primary Hepatic Carcinoma and Metastatic Hepatic Carcinoma
10.3969/j.issn.1671-7414.2015.01.042
- VernacularTitle:血清唾液酸在原发性肝癌和转移性肝癌诊断中的临床价值
- Author:
Wang SHEN
;
Wenli YANG
;
Liyan YE
;
Chenjuan HUANG
;
Yuegui LI
- Publication Type:Journal Article
- Keywords:
sialic acid;
alpha-fetoprotein;
primary hepatic carcinoma;
metastatic hepatic carcinoma
- From:
Journal of Modern Laboratory Medicine
2015;(1):140-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the diagnostic and distinguishing diagnostic value in primary hepatic carcinoma (PHC)and metastatic hepatic carcinoma (MHC)by the serum sialic acid (SA)detection.Methods During January 2012 to June 2014, 100 cases of patients with PHC,91 cases of patients with MHC,155 cases of benign liver disease patients,and 139 healthy people in Wuyi Traditional Chinese Medicine Hospital were included into the study.The concentration of serum SA and AFP were detected by chemical enzymatic method and chemiluminescence method,SPSS1 9.0 was used to analysis the results.Re-sults The concentration of serum SA in PHC patients (701.08±189.33 mg/L)were significantly higher than benign liver disease patients (588.38±98.51 mg/L)and healthy people (572.37±89.13 mg/L),there was statistical significance (P=0.000),the significantly statistical differences were also in MHC (790.20±162.29 mg/L)and PHC patients (P=0.027). Serum SA in the diagnosis of MHC sensitivity,specificity and AUC were 84.6%,85.2% and 0.895,compared with serum AFP (sensitivity 22.2%,specificity 29.6% and AUC 0.301)had statistically significance (P=0.000).Conclusion The se-rum SA has important clinical significance in the diagnosis and distinguishing diagnosis of PHC and MHC.
