Study of the Correlation of Testing Results by Two Different D-dimer Reagents with Fibrin Degradation Products Result Values
10.3969/j.issn.1671-7414.2015.01.030
- VernacularTitle:两种试剂D-二聚体检测值与纤维蛋白降解产物值的相关性研究
- Author:
Sha LIU
;
Yongmei JIANG
;
Ge ZHANG
;
Yali CUI
- Publication Type:Journal Article
- Keywords:
D-dimer;
FDP;
Siemens D-Dimer Plus Reagent;
Innovance D-DIMER Reagent
- From:
Journal of Modern Laboratory Medicine
2015;(1):108-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical practicality of two different D-dimer assays by studying the correlation of the testing results by two different D-dimer reagents with fibrin degradation products (FDP)result values and analyzing the Clinical alignment.Methods A representative cross-sectional study of 762 clinical patients’plasma specimens were taken to measure the results of D-dimer and FDP by using Sysmex CA-1500 automated coagulation analyzer,D-DIMER detection rea-gent respectively Siemens Innovance D-DIMER and Dade Behring D-DIMER Plus reagents.Then rating frequency analysis and Spearman correlation test were applied to analyze the correlation of measurement results.Results Overall,to the same patient,the correlation of D-dimer tested by Siemens Innovance D-DIMER Reagent with FDP level was significant positive (r= 0.954,P<0.01),better than that tested by Siemens DD Plus Reagent (r=0.885,P<0.01);and this correlation had an increasing trend when D-dimer level raised.When D-dimer level > 5 mg/L FEU,the correlation was the best (P<0.01). And by calculating the amount of positive FDP (FDP>5μg/ml)and FDP positive rate in both different cases when D-dimer results was also positive,FDP positive rate in Innovance D-DIMER Reagent group (about 65.76%)was lower than DD Plus Reagent group,it indicated that D-dimer results tested by Innovance D-DIMER Reagent could raise before FDP reacted,so D-dimer had a higher sensitivity than FDP.Conclusion It can provide a more precise clinical diagnosis and treatment infor-mation when using Siemens Innovance D-DIMER Reagent to detect D-dimer values and combined FDP values at the same time.
