Role of Haptoglobin in the Immunomodulatory in Patients with Premature Coronary Heart Disease
10.3969/j.issn.1671-7414.2015.01.027
- VernacularTitle:早发冠心病触珠蛋白水平及其在免疫调节中的作用研究
- Author:
Yao LI
;
Ping YANG
- Publication Type:Journal Article
- Keywords:
coronary heart disease;
haptoglobin;
high-sensitivity C-reactive protein;
interleukin-6
- From:
Journal of Modern Laboratory Medicine
2015;(1):98-100
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyse the role of haptoglobin in the immunomodulatory in patients with premature coronary heart disease.Methods Clinical data of 60 premature coronary heart disease patients and 40 healthy people was analysed.The general information and serume haptoglobin,hs-CRP and IL-6 were compared.Results There were no statistically difference between the two groups of the general information such as sex,years,BMI,hypertension and diabetes (P>0.05),excepts the smoking history(27/33 vs 9/31,χ2=3.324,P<0.05).Hp,hs-CRP and IL-6 levels in the observer group were signifi-cantly higher than the control group,the difference was statistically significant (97.76±23.08 mg/L vs 65.81±19.42 mg/L,10.43±3.81 mg/L vs 3.05±0.94 mg/L,16.43±4.59 pg/L vs 4.62±1.83 pg/L,P<0.001).Correlation analysis showed that in the observer group Hp and hs-CRP showed a significant positive correlation (r=0.518,P<0.001),and the same results was found between IL-6 and Hp (r= 0.291,P=0.024).Conclusion Haptoglobin level was significantly in-creased in patients with coronary heart disease,which suggested that haptoglobin played a role in the development of coro-nary heart disease,and its level was correlated with IL-6.
