Clinical Application of Urinary Transforming Growth Factor-Beta(TGF-β1)Measurement in Diagnosing Chronic Nephritis
10.3969/j.issn.1671-7414.2015.01.024
- VernacularTitle:尿TGF-β1检测在诊断慢性肾炎中的临床应用
- Author:
Xiaoli WANG
;
Ruidong LIU
- Publication Type:Journal Article
- Keywords:
TGF-β1;
MPG;
FGS;
IgA N
- From:Journal of Modern Laboratory Medicine
2015;(1):88-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the level of urinary TGF-β1 and evaluate its clinical significance in patients with chronic nephritis.Methods 22 healthy people and 40 patients with chronic nephritis were selected,the levels of urinary TGF-β1 were measured by RT-PCR and ELISA.Results Urinary TGF-β1 were significantly increased in Mesangial Proliferative Glomerulonephritis (76.44± 24.29 ng/mmol.Cr vs 31.53 ± 11.59 ng/mmol.Cr,P<0.01);Focal Glomerular Sclerosis (65.07±20.59 ng/mmol.Cr vs 31.53±11.59 ng/mmol.Cr,P<0.01)and IgA Nephritis (67.01±21.95 ng/mmol.Cr vs 31.53±11.59 ng/mmol.Cr,P<0.01),comparing with normal group.Conclusion The levels of urinary TGF-β1 could be a predictor in reflecting the sate of renal diease,estimating pathological type,diagnosing the renal diease and observing the therapeutic effects.
