Research Progress ofβ2 GlycoproteinⅠ and Anti-β2GPⅠ Antibodies and Antiphospholipid Syndrome
10.3969/j.issn.1671-7414.2015.01.006
- VernacularTitle:β2 GPⅠ及其抗体与抗磷脂综合征的研究进展
- Author:
Na SUN
;
Wenjing ZHANG
;
Fei GAO
;
Yanhong LIU
- Publication Type:Journal Article
- Keywords:
β2-glycoproteinⅠ;
anti-β2GPⅠantibody;
antiphospholipid syndrome
- From:Journal of Modern Laboratory Medicine
2015;(1):19-22
- CountryChina
- Language:Chinese
-
Abstract:
Antiphospholipid syndrome (APS)is an autoimmune multisystem disorder characterized clinically by recurrent thrombosis and pregnancy morbidity.β2-glycoproteinⅠ (β2GPⅠ)is the major antigen in the APS.Anti-β2GPⅠ antibody is the autoantibody which targets toβ2GPⅠ.There is overwhelming evidence thatβ2GPⅠand anti-β2GPⅠ antibody play an important role in the pathogenesis of APS.Now the diagnosis and treatment of anti-β2GPⅠ antibody are more and more get people's attention,detection of anti-β2GPⅠDⅠ antibody can specifically diagnose APS and research of the molecular level may provide a new therapeutic target for APS.In this paper,β2GPⅠ,anti-β2GPⅠ antibody and APS associated development were reviewed.
